GSBS Student Publications

Title

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Medicine; Department of Pathology

Date

1-1-1996

Document Type

Article

Medical Subject Headings

Animals; DNA, Viral; Gene Products, env; Histocompatibility Antigens Class I; Macaca mulatta; Plasmids; Retroviridae Proteins; Simian immunodeficiency virus; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Vaccines, Synthetic; Viral Envelope Proteins; Viral Vaccines

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine.

Rights and Permissions

Citation: J Virol. 1996 Jan;70(1):678-81.

Related Resources

Link to Article in PubMed

Journal Title

Journal of virology

PubMed ID

8523593