Early studies on DNA-based immunizations for measles virus
Graduate School of Biomedical Sciences; Department of Pathology
Medical Subject Headings
Animals; Antibodies, Viral; Biolistics; Cercopithecus aethiops; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Measles Vaccine; Measles virus; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Rabbits; Vaccines, DNA; Vero Cells
Life Sciences | Medicine and Health Sciences
DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.
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Citation: Vaccine. 1997 Jun;15(8):888-91.
Yang, Hyekyung; Mustafa, Farah; Valsamakis, Alexandra; Santoro, Joseph C.; Griffin, Diane E.; and Robinson, Harriet L., "Early studies on DNA-based immunizations for measles virus" (1997). GSBS Student Publications. 752.