Title

Ribo-gnome: the big world of small RNAs

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Graduate School of Biomedical Sciences

Date

9-6-2005

Document Type

Article

Medical Subject Headings

Animals; Binding Sites; Cell Nucleus; History, 20th Century; Humans; MicroRNAs; Models, Genetic; Molecular Biology; *RNA Interference; RNA, Messenger; RNA, Small Interfering; Stem Cells

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Small RNA guides--microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length--shape diverse cellular pathways, from chromosome architecture to stem cell maintenance. Fifteen years after the discovery of RNA silencing, we are only just beginning to understand the depth and complexity of how these RNAs regulate gene expression and to consider their role in shaping the evolutionary history of higher eukaryotes.

Rights and Permissions

Citation: Science. 2005 Sep 2;309(5740):1519-24. Link to article on publisher's site

Related Resources

Link to Article in PubMed