Ribo-gnome: the big world of small RNAs
Department of Biochemistry and Molecular Pharmacology; Graduate School of Biomedical Sciences
Medical Subject Headings
Animals; Binding Sites; Cell Nucleus; History, 20th Century; Humans; MicroRNAs; Models, Genetic; Molecular Biology; *RNA Interference; RNA, Messenger; RNA, Small Interfering; Stem Cells
Life Sciences | Medicine and Health Sciences
Small RNA guides--microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length--shape diverse cellular pathways, from chromosome architecture to stem cell maintenance. Fifteen years after the discovery of RNA silencing, we are only just beginning to understand the depth and complexity of how these RNAs regulate gene expression and to consider their role in shaping the evolutionary history of higher eukaryotes.
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Citation: Science. 2005 Sep 2;309(5740):1519-24. Link to article on publisher's site