Nuclear microenvironments in biological control and cancer
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Active Transport, Cell Nucleus; Cell Compartmentation; Cell Nucleus; Core Binding Factor alpha Subunits; *Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Neoplasms; Nuclear Matrix; Regulatory Sequences, Nucleic Acid
Life Sciences | Medicine and Health Sciences
Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.
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Citation: Nat Rev Cancer. 2007 Jun;7(6):454-63. Link to article on publisher's site