GSBS Student Publications

Title

Nuclear microenvironments in biological control and cancer

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Date

5-25-2007

Document Type

Article

Medical Subject Headings

Active Transport, Cell Nucleus; Cell Compartmentation; Cell Nucleus; Core Binding Factor alpha Subunits; *Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Neoplasms; Nuclear Matrix; Regulatory Sequences, Nucleic Acid

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

Rights and Permissions

Citation: Nat Rev Cancer. 2007 Jun;7(6):454-63. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Nature reviews. Cancer

PubMed ID

17522714