Authors
Zaidi, Sayyed K.Young, Daniel W.
Javed, Amjad
Pratap, Jitesh
Montecino, Martin A.
Van Wijnen, Andre J.
Lian, Jane B.
Stein, Janet L.
Stein, Gary S.
Document Type
Journal ArticlePublication Date
2007-05-25Keywords
Active Transport, Cell Nucleus; Cell Compartmentation; Cell Nucleus; Core Binding Factor alpha Subunits; *Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Neoplasms; Nuclear Matrix; Regulatory Sequences, Nucleic AcidLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.Source
Nat Rev Cancer. 2007 Jun;7(6):454-63. Link to article on publisher's siteDOI
10.1038/nrc2149Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34066PubMed ID
17522714Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/nrc2149