The dynamic organization of gene-regulatory machinery in nuclear microenvironments
Department of Cell Biology; Graduate School of Biomedical Sciences
Medical Subject Headings
Animals; Cell Nucleus; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Gene Expression Regulation; Humans; Nuclear Matrix; Protein Transport; Proto-Oncogene Proteins; Transcription Factors; Transcription, Genetic
Life Sciences | Medicine and Health Sciences
Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.
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Citation: EMBO Rep. 2005 Feb;6(2):128-33. Link to article on publisher's site