Department of Cell Biology; Graduate School of Biomedical Sciences
Medical Subject Headings
Cell Nucleus; Cell Physiology; DNA; Gene Expression; Homeostasis; Models, Biological; Proteins; Signal Transduction
Life Sciences | Medicine and Health Sciences
The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.
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First published as: J Biol Chem. 2004 Oct 15;279(42):43363-6. Epub 2004 Jul 23. Link to article on publisher's site