UMMS Affiliation

Department of Cell Biology; Graduate School of Biomedical Sciences



Document Type


Medical Subject Headings

Cell Nucleus; Cell Physiology; DNA; Gene Expression; Homeostasis; Models, Biological; Proteins; Signal Transduction


Life Sciences | Medicine and Health Sciences


The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

Rights and Permissions

First published as: J Biol Chem. 2004 Oct 15;279(42):43363-6. Epub 2004 Jul 23. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID