GSBS Student Publications


Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation

GSBS Program

Cell Biology

UMMS Affiliation

Department of Cell Biology



Document Type


Medical Subject Headings

Animals; Cell Differentiation; Cell Division; Gene Expression Regulation, Developmental; Humans; Osteoblasts; Osteocalcin; Promoter Regions (Genetics)


Cell Biology | Life Sciences | Medicine and Health Sciences


The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restricted expression. Over the last decade, characterization of the promoter regulatory elements and complexes of factors that control suppression of the osteocalcin gene in osteoprogenitor cells and transactivation in mature osteoblasts has revealed transcriptional regulatory mechanisms that mediate development of the osteoblast phenotype. In this review, we have focused on emerging concepts related to molecular mechanisms supporting osteoblast growth and differentiation based on the discoveries that the osteocalcin gene is regulated by homeodomain factors, AP-1 related proteins, and the bone restricted Cbfa1/AML3 transcription factor.

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Citation: J Cell Biochem Suppl. 1998;30-31:62-72.

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Link to article in PubMed

PubMed ID