Genomic loci of human mitogen-activated protein kinases
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Molecular Medicine and Howard Hughes Medical Institute
Medical Subject Headings
Calcium-Calmodulin-Dependent Protein Kinases; *Chromosome Mapping; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 22; Enzyme Activation; Genes; *Genome, Human; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 6; *Mitogen-Activated Protein Kinases; Signal Transduction
Life Sciences | Medicine and Health Sciences
Mitogen-activated protein (MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. Several components of the MAP kinase signal transduction pathway have been demonstrated to be oncogenically activated in malignant tumors. These include growth factor receptors, the GTP-binding protein Ras, and the protein kinase Raf. The genes that encode MAP kinases therefore represent potential targets of carcinogenic insults. Here, we report the genomic loci of three MAP kinase genes are widely distributed within the human genome: p41mapk (Erk2) at 22q11.2; p44mapk (Erk1) at 16p11.2; and p63mapk (Erk3-related) at 18q12-21.
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Citation: Oncogene. 1994 Feb;9(2):647-9.
Li, Li; Wysk, Mark Allen; Gonzalez, Fernando A.; and Davis, Roger J., "Genomic loci of human mitogen-activated protein kinases" (1994). GSBS Student Publications. 683.