GSBS Student Publications

Title

Genomic loci of human mitogen-activated protein kinases

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and Howard Hughes Medical Institute

Date

2-1-1994

Document Type

Article

Medical Subject Headings

Calcium-Calmodulin-Dependent Protein Kinases; *Chromosome Mapping; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 22; Enzyme Activation; Genes; *Genome, Human; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 6; *Mitogen-Activated Protein Kinases; Signal Transduction

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Mitogen-activated protein (MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. Several components of the MAP kinase signal transduction pathway have been demonstrated to be oncogenically activated in malignant tumors. These include growth factor receptors, the GTP-binding protein Ras, and the protein kinase Raf. The genes that encode MAP kinases therefore represent potential targets of carcinogenic insults. Here, we report the genomic loci of three MAP kinase genes are widely distributed within the human genome: p41mapk (Erk2) at 22q11.2; p44mapk (Erk1) at 16p11.2; and p63mapk (Erk3-related) at 18q12-21.

Rights and Permissions

Citation: Oncogene. 1994 Feb;9(2):647-9.

Related Resources

Link to article in PubMed

Journal Title

Oncogene

PubMed ID

8290275