Student Author(s)

Calin Stoicov

GSBS Program

Cancer Biology

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Date

2-21-2006

Document Type

Article

Medical Subject Headings

Animals; Bone Marrow Cells; Humans; *Inflammation; Models, Theoretical; Neoplasms, Glandular and Epithelial; Stem Cells

Disciplines

Gastroenterology | Life Sciences | Medicine and Health Sciences

Abstract

Cancer commonly arises at the sites of chronic inflammation and infection. Although this association has long been recognized, the reason has remained unclear. Within the gastrointestinal tract, there are many examples of inflammatory conditions associated with cancer, and these include reflux disease and Barrettos adenocarcinoma of the esophagus, Helicobacter infection and gastric cancer, inflammatory bowel disease and colorectal cancer and viral hepatitis leading to hepatocellular carcinoma. There are several mechanisms by which chronic inflammation has been postulated to lead to cancer which includes enhanced proliferation in an endless attempt to heal damage, the presence of a persistent inflammatory environment creating a pro-carcinogenic environment and more recently a role for engraftment of circulating marrow-derived stem cells which may contribute to the stromal components of the tumor as well as the tumor mass itself. Here we review the recent advances in our understanding of the contributions of circulating bone marrow-derived stem cells to the formation of tumors in animal models as well as in human beings.

Rights and Permissions

Citation: World J Gastroenterol. 2006 Jan 21;12(3):363-71. Link to article on publisher's website

Related Resources

Link to article in PubMed

PubMed ID

16489634