GSBS Student Publications

Title

JunD mediates survival signaling by the JNK signal transduction pathway

UMMS Affiliation

Graduate School of Biomedical Sciences; Howard Hughes Medical Institute and Program in Molecular Medicine

Date

6-25-2003

Document Type

Article

Medical Subject Headings

Animals; Apoptosis; Cell Line; Cell Survival; DNA Fragmentation; Enzyme Activation; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Mice; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; Protein Isoforms; Proto-Oncogene Proteins c-jun; *Signal Transduction; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The c-Jun NH(2)-terminal kinase (JNK) can cause cell death by activating the mitochondrial apoptosis pathway. However, JNK is also capable of signaling cell survival. The mechanism that accounts for the dual role of JNK in apoptosis and survival signaling has not been established. Here we demonstrate that JNK-stimulated survival signaling can be mediated by JunD. The JNK/JunD pathway can collaborate with NF-kappaB to increase antiapoptotic gene expression. This observation accounts for the ability of JNK to cause either survival or apoptosis in different cellular contexts. Furthermore, these data illustrate the general principal that signal transduction pathway integration is critical for the ability of cells to mount an appropriate biological response to a specific challenge.

Rights and Permissions

Citation: Mol Cell. 2003 Jun;11(6):1479-89.

Related Resources

Link to article in PubMed

Journal Title

Molecular cell

PubMed ID

12820962