GSBS Student Publications

Title

Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Medicine, Division of Infectious Diseases and Immunology; Center for Infectious Disease and Vaccine Research

Date

1-1-1994

Document Type

Article

Medical Subject Headings

Cross Reactions; Dengue; Humans; Immunity, Cellular; Immunologic Memory; Lymphocyte Activation; Models, Biological; Shock, Septic; Syndrome; T-Lymphocytes, Cytotoxic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Dengue virus infections are a major cause of morbidity and mortality in tropical and subtropical areas of the world. The immunopathological mechanisms that result in severe complications of dengue virus infection, i.e. dengue hemorrhagic fever (DHF), are important to determine. Primary dengue virus infections induce serotype-specific and serotype-cross-reactive, CD4+ and CD8+ memory cytotoxic T lymphocytes (CTL). In secondary infections with a virus of a different serotype from that which caused primary infections, the presence of cross-reactive non-neutralizing antibodies results in an increased number of infected monocytes by dengue virus--antibody complexes. This in turn results in marked activation of serotype cross-reactive CD4+ and CD8+ memory CTL. We hypothesize that the rapid release of cytokines and chemical mediators caused by T cell activation and by CTL-mediated lysis of dengue virus-infected monocytes triggers the plasma leakage and hemorrhage that occurs in DHF.

Rights and Permissions

Citation: Arch Virol Suppl. 1994;9:59-64.

Related Resources

Link to article in PubMed

Journal Title

Archives of virology. Supplementum

PubMed ID

8032282