GSBS Student Publications

Title

Itk and Th2 responses: action but no reaction

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Date

8-26-2006

Document Type

Article

Medical Subject Headings

Animals; Cell Differentiation; Humans; Lymphocyte Activation; Protein-Tyrosine Kinases; Signal Transduction; Th2 Cells

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The Tec family tyrosine kinase, Itk, was initially characterized as a crucial component of T-cell receptor signaling pathways resulting in phospholipase C-gamma1 activation and actin polymerization. In 1999, a seminal report by Fowell, Locksley and colleagues demonstrated that, in CD4+ T cells, Itk-dependent signals are differentially required for T-helper (Th)2 versus Th1 differentiation and effector function. These findings launched a series of in vitro and in vivo studies addressing the molecular defects of Itk-/- CD4+ T cells, and the impaired immune responses of intact Itk-deficient mice. While demonstrating a bias against Th2 differentiation, overall these experiments have indicated that the most significant failing is an inability of Itk-/- CD4+ T cells to produce Th2 cytokines in a recall response, rather than an absolute defect in Th2 differentiation by T cells lacking Itk. In this review, we discuss the pathways by which Itk might impact the differentiation of Th cells.

Rights and Permissions

Citation: Trends Immunol. 2006 Oct;27(10):453-60. Epub 2006 Aug 22. Link to article on publisher's site

DOI of Published Version

10.1016/j.it.2006.08.006

Related Resources

Link to article in PubMed

Journal Title

Trends in immunology

PubMed ID

16931156