GSBS Student Publications

Title

Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output

Student Author(s)

Alex Keene; Paola Perrat

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

10-28-2004

Document Type

Article

Medical Subject Headings

Analysis of Variance; Animals; Animals, Genetically Modified; Avoidance Learning; Behavior, Animal; Benzaldehydes; Brain; Conditioning (Psychology); Drosophila; Drosophila Proteins; Fushi Tarazu Transcription Factors; Histocytochemistry; Maze Learning; Memory; Microscopy, Confocal; Mushroom Bodies; Mutagenesis; Neurons; Neuropeptides; *Odors; Olfactory Pathways; Recombinant Fusion Proteins; Temperature; Time Factors; Trans-Activators

Disciplines

Neuroscience and Neurobiology

Abstract

Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration.

Rights and Permissions

Citation: Neuron. 2004 Oct 28;44(3):521-33. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Neuron

PubMed ID

15504331