GSBS Student Publications

Title

STAT5 is required for thymopoiesis in a development stage-specific manner

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Date

8-6-2004

Document Type

Article

Medical Subject Headings

Animals; Cells, Cultured; DNA-Binding Proteins; Flow Cytometry; Gene Rearrangement; Genes, T-Cell Receptor gamma; Immunohistochemistry; Interleukin-7; *Lymphopoiesis; Mice; *Milk Proteins; Peyer's Patches; Polymerase Chain Reaction; Receptors, Interleukin-7; STAT5 Transcription Factor; T-Lymphocytes; Thymus Gland; Trans-Activators; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Diverse cytokines necessary for normal lymphopoiesis and lymphocyte homeostasis activate STAT5 in responder cells. Although STAT5 has been suggested to be a central molecular effecter of IL-7 function, its essential role during IL-7-dependent T cell development in vivo remained unclear. Using Stat5(-/-) mice we now show that STAT5 is essential for various functions ascribed to IL-7 in vivo. STAT5 is required for embryonic thymocyte production, TCRgamma gene transcription, and Peyer's patch development. In sharp contrast, normal STAT5 is dispensable for adult thymopoiesis. In peripheral lymphocytes, STAT5 is primarily required for the generation and/or maintenance of gammadelta T cells and TCRgammadelta(+) intraepithelial lymphocytes. Collectively, these results demonstrate that STAT5 is critical for many, but not all, aspects of steady state lymphoid lineage development and maintenance and suggest the existence of previously undocumented cytokine signaling traits and/or cytokine milieu during adult thymopoiesis.

Rights and Permissions

Citation: J Immunol. 2004 Aug 15;173(4):2307-14.

Related Resources

Link to article in PubMed

Journal Title

Journal of immunology (Baltimore, Md. : 1950)

PubMed ID

15294943