Cutting edge: MHC class II-restricted killing in vivo during viral infection
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology
Medical Subject Headings
Adoptive Transfer; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, CD95; Antigens, Viral; CD4-Positive T-Lymphocytes; *Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Fas Ligand Protein; Glycoproteins; Histocompatibility Antigens Class II; Influenza A virus; Lymphocyte Depletion; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Receptors, Antigen, T-Cell, alpha-beta; Spleen; Viral Proteins
Life Sciences | Medicine and Health Sciences
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
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Citation: J Immunol. 2005 Jan 15;174(2):614-8.