GSBS Student Publications

Title

Gastric cancer originating from bone marrow-derived cells

Student Author(s)

Calin Stoicov,

GSBS Program

Cancer Biology

UMMS Affiliation

Department of Medicine, Division of Gastroenterology; Department of Cancer Biology

Date

11-30-2004

Document Type

Article

Medical Subject Headings

Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma in Situ; Cell Differentiation; Cell Fusion; Disease Progression; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; *Helicobacter felis; Keratins; Male; Mesenchymal Stem Cells; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mucins; Muscle Proteins; Parietal Cells, Gastric; Peptides; Phenotype; Stem Cells; Stomach Neoplasms

Disciplines

Gastroenterology | Life Sciences | Medicine and Health Sciences

Abstract

Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.

Rights and Permissions

Citation: Science. 2004 Nov 26;306(5701):1568-71. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Science (New York, N.Y.)

PubMed ID

15567866