Endoplasmic reticulum stress signaling in pancreatic beta-cells
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Gene Function and Expression; Program in Molecular Medicine
Medical Subject Headings
Animals; Endoplasmic Reticulum; Humans; Insulin-Secreting Cells; Models, Biological; Pancreas; *Signal Transduction; *Stress
Life Sciences | Medicine and Health Sciences
Pancreatic beta-cells are specialized for the production and regulated secretion of insulin to control blood-glucose levels. Increasing evidence indicates that stress-signaling pathways emanating from the endoplasmic reticulum (ER) are important in the maintenance of beta-cell homeostasis. Under physiological conditions, ER stress signaling has beneficial effects on beta-cells. Timely and proper activation of ER stress signaling is crucial for generating the proper amount of insulin in proportion to the need for it. In contrast, chronic and strong activation of ER stress signaling has harmful effects, leading to beta-cell dysfunction and death. Therefore, to dissect the molecular mechanisms of beta-cell failure and death in diabetes, it is necessary to understand the complex network of ER stress-signaling pathways. This review focuses on the function of the ER stress-signaling network in pancreatic beta-cells.
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Citation: Antioxid Redox Signal. 2007 Dec;9(12):2335-44. Link to article on publisher's site
Antioxidants and redox signaling
Fonseca, Sonya G.; Lipson, Kathryn L.; and Urano, Fumihiko, "Endoplasmic reticulum stress signaling in pancreatic beta-cells" (2007). GSBS Student Publications. 520.