GSBS Student Publications

Title

Sequential use of mushroom body neuron subsets during drosophila odor memory processing

Student Author(s)

Michael Krashes; Alex Keene

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

1-2-2007

Document Type

Article

Medical Subject Headings

Animals; Animals, Genetically Modified; Avoidance Learning; Drosophila; Electric Stimulation; Gene Expression Regulation, Developmental; Memory; Mushroom Bodies; Mutation; Nerve Net; Neural Pathways; Neurons; *Odors; Smell; Synaptic Transmission

Disciplines

Neuroscience and Neurobiology

Abstract

Drosophila mushroom bodies (MB) are bilaterally symmetric multilobed brain structures required for olfactory memory. Previous studies suggested that neurotransmission from MB neurons is only required for memory retrieval. Our unexpected observation that Dorsal Paired Medial (DPM) neurons, which project only to MB neurons, are required during memory storage but not during acquisition or retrieval, led us to revisit the role of MB neurons in memory processing. We show that neurotransmission from the alpha'beta' subset of MB neurons is required to acquire and stabilize aversive and appetitive odor memory, but is dispensable during memory retrieval. In contrast, neurotransmission from MB alphabeta neurons is only required for memory retrieval. These data suggest a dynamic requirement for the different subsets of MB neurons in memory and are consistent with the notion that recurrent activity in an MB alpha'beta' neuron-DPM neuron loop is required to stabilize memories formed in the MB alphabeta neurons.

Rights and Permissions

Citation: Neuron. 2007 Jan 4;53(1):103-15. Link to article on publisher's site

DOI of Published Version

10.1016/j.neuron.2006.11.021

Related Resources

Link to Article in PubMed

Journal Title

Neuron

PubMed ID

17196534