GSBS Student Publications

Title

SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine

Date

4-18-2007

Document Type

Article

Medical Subject Headings

Adenosine Triphosphatases; Galactokinase; Genes, Fungal; Glucose; Histones; Multigene Family; Nuclear Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; *Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Post-translational modification of nucleosomal histones has been suggested to contribute to epigenetic transcriptional memory. We describe a case of transcriptional memory in yeast where the rate of transcriptional induction of GAL1 is regulated by the prior expression state. This epigenetic state is inherited by daughter cells, but does not require the histone acetyltransferase, Gcn5p, the histone ubiquitinylating enzyme, Rad6p, or the histone methylases, Dot1p, Set1p, or Set2p. In contrast, we show that the ATP-dependent chromatin remodeling enzyme, SWI/SNF, is essential for transcriptional memory at GAL1. Genetic studies indicate that SWI/SNF controls transcriptional memory by antagonizing ISWI-like chromatin remodeling enzymes.

Rights and Permissions

Citation: Genes Dev. 2007 Apr 15;21(8):997-1004. Link to article on publisher's site

DOI of Published Version

10.1101/gad.1506607

Related Resources

Link to Article in PubMed

Journal Title

Genes and development

PubMed ID

17438002