GSBS Student Publications

Title

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity

Student Author(s)

Marie King

UMMS Affiliation

Department of Medicine, Division of Diabetes; Department of Medicine, Division of Endocrinology and Metabolism

Date

3-23-2007

Document Type

Article

Medical Subject Headings

Animals; Crosses, Genetic; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Islets of Langerhans; Isoantigens; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID

Disciplines

Allergy and Immunology | Endocrinology, Diabetes, and Metabolism | Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

The use of "humanized" mice represents an appealing translational model for studies of the pathogenesis of immune-mediated diseases and for the evaluation of potential therapeutics. The utility of humanized mice depends on their ability to model the human immune system with high fidelity, and, in this respect, previous models have fallen short. The recently developed NOD-scid Il2rgamma(null) mouse, however, exhibits greatly enhanced ability to support the engraftment of human peripheral blood mononuclear cells. Herein, we describe the challenges of recapitulating human immunity in humanized mice and features of NOD-scid Il2rgamma(null) mice that help overcome them.

Rights and Permissions

Citation: Ann N Y Acad Sci. 2007 Apr;1103:90-3. Epub 2007 Mar 21. Link to article on publisher's site

DOI of Published Version

10.1196/annals.1394.011

Related Resources

Link to Article in PubMed

Journal Title

Annals of the New York Academy of Sciences

PubMed ID

17376822