A radical role for p38 MAPK in tumor initiation
Graduate School of Biomedical Sciences, MD/PhD Program; Program in Molecular Medicine
Medical Subject Headings
Animals; Apoptosis; *Cell Transformation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 14; Neoplasms; *Oxidative Stress; Reactive Oxygen Species; Signal Transduction
Cancer Biology | Life Sciences | Medicine and Health Sciences
It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress.
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Citation: Cancer Cell. 2007 Feb;11(2):101-3. Link to article on publisher's site