GSBS Student Publications

Title

RNAi (Nematodes: Caenorhabditis elegans)

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology; Program in Molecular Medicine

Date

4-5-2002

Document Type

Article

Medical Subject Headings

Animals; Animals, Genetically Modified; Caenorhabditis elegans; *Caenorhabditis elegans Proteins; DNA Transposable Elements; *Gene Silencing; Genes, Helminth; Helminth Proteins; Models, Genetic; Multigene Family; Mutation; RNA Replicase; RNA, Helminth; Suppression, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as characterized components of the RNAi, pathway, the molecular mechanism of RNAi, and its possible role in development and immunity.

Rights and Permissions

Citation: Adv Genet. 2002;46:339-60.

Related Resources

Link to article in PubMed

Journal Title

Advances in genetics

PubMed ID

11931230