GSBS Student Publications


RNAi (Nematodes: Caenorhabditis elegans)

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology; Program in Molecular Medicine



Document Type


Medical Subject Headings

Animals; Animals, Genetically Modified; Caenorhabditis elegans; *Caenorhabditis elegans Proteins; DNA Transposable Elements; *Gene Silencing; Genes, Helminth; Helminth Proteins; Models, Genetic; Multigene Family; Mutation; RNA Replicase; RNA, Helminth; Suppression, Genetic


Life Sciences | Medicine and Health Sciences


RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as characterized components of the RNAi, pathway, the molecular mechanism of RNAi, and its possible role in development and immunity.

Rights and Permissions

Citation: Adv Genet. 2002;46:339-60.

Related Resources

Link to article in PubMed

Journal Title

Advances in genetics

PubMed ID