RNAi (Nematodes: Caenorhabditis elegans)
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Cell Biology; Program in Molecular Medicine
Medical Subject Headings
Animals; Animals, Genetically Modified; Caenorhabditis elegans; *Caenorhabditis elegans Proteins; DNA Transposable Elements; *Gene Silencing; Genes, Helminth; Helminth Proteins; Models, Genetic; Multigene Family; Mutation; RNA Replicase; RNA, Helminth; Suppression, Genetic
Life Sciences | Medicine and Health Sciences
RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as characterized components of the RNAi, pathway, the molecular mechanism of RNAi, and its possible role in development and immunity.
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Citation: Adv Genet. 2002;46:339-60.