GSBS Student Publications

Title

NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Neuroregeneration Laboratory

Date

11-4-1996

Document Type

Article

Medical Subject Headings

Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Male; Nerve Growth Factors; Nitro Compounds; Propionic Acids; Rats; Rats, Sprague-Dawley; Tyrosine

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Nerve growth factor (NGF)-secreting fibroblasts are able to protect against the Huntington-like striatal neurodegeneration induced by the mitochondrial toxin 3-nitropropionic acid (3-NP). In the present study, we investigated whether the neuroprotective effects of NGF are mediated through antioxidative mechanisms. Rats were grafted in the corpus callosum with NGF[+] or NGF[-] fibroblasts 7 days before administration of 3-NP. The generation of peroxynitrite was evaluated by measuring the striatal levels of 3-nitrotyrosine. NGF significantly decreased the 3-NP induced generation of 3-nitrotyrosine, presumably by decreasing peroxynitrite formation. These findings suggest that NGF might protect against neuronal death by inhibiting the production of nitric oxide or decreasing the levels of superoxide radicals, thereby decreasing the generation of oxidative agents such as peroxynitrite.

Rights and Permissions

Citation: Neuroreport. 1996 Nov 4;7(15-17):2639-42.

Related Resources

Link to article in PubMed

Journal Title

Neuroreport

PubMed ID

8981438