Title

Progress, paradox, and potential: parathyroid hormone research over five decades

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences

Date

12-7-2007

Document Type

Article

Medical Subject Headings

Amino Acid Sequence; Animals; Biology; Cattle; Evolution, Molecular; Humans; Ligands; Models, Biological; Molecular Conformation; Molecular Sequence Data; Osteoporosis; Parathyroid Glands; Parathyroid Hormone; Receptor, Parathyroid Hormone, Type 1

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

With the advent of advances in chemical and molecular biology, the structure of parathyroid hormone (PTH); the related protein, parathyroid-related protein (PTHrP); and their principal receptor (PTH/PTHrP receptor [PTHR1]) were established over recent decades. Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments plus recent insights into previously unappreciated ligand-receptor conformations that cause prolonged biological activation have stimulated the field of calcium and bone biology and posed new questions about the role of PTH and PTHrP as well as possible new directions in the therapy of osteoporosis and calcium-deficit states.

Rights and Permissions

Citation: Ann N Y Acad Sci. 2007 Nov;1117:196-208. Link to article on publisher's site

Related Resources

Link to Article in PubMed