Progress, paradox, and potential: parathyroid hormone research over five decades
UMass Chan Affiliations
Graduate School of Biomedical SciencesDocument Type
Journal ArticlePublication Date
2007-12-07Keywords
Amino Acid Sequence; Animals; Biology; Cattle; Evolution, Molecular; Humans; Ligands; Models, Biological; Molecular Conformation; Molecular Sequence Data; Osteoporosis; Parathyroid Glands; Parathyroid Hormone; Receptor, Parathyroid Hormone, Type 1Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
With the advent of advances in chemical and molecular biology, the structure of parathyroid hormone (PTH); the related protein, parathyroid-related protein (PTHrP); and their principal receptor (PTH/PTHrP receptor [PTHR1]) were established over recent decades. Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments plus recent insights into previously unappreciated ligand-receptor conformations that cause prolonged biological activation have stimulated the field of calcium and bone biology and posed new questions about the role of PTH and PTHrP as well as possible new directions in the therapy of osteoporosis and calcium-deficit states.Source
Ann N Y Acad Sci. 2007 Nov;1117:196-208. Link to article on publisher's siteDOI
10.1196/annals.1402.088Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33682PubMed ID
18056044Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1196/annals.1402.088