Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS)
Authors
Ennis, Francis A.Cruz, John
Jameson, Julie Marie
Klein, Michael D.
Burt, David
Thipphawong, John
Student Authors
Julie Marie JamesonUMass Chan Affiliations
Center for Infectious Disease and Vaccine ResearchDocument Type
Journal ArticlePublication Date
1999-07-05Keywords
Adolescent; Adult; Double-Blind Method; Humans; ISCOMs; *Immunologic Memory; Influenza A virus; Influenza Vaccines; Middle Aged; T-Lymphocytes, Cytotoxic; VaccinationImmunology and Infectious Disease
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
There is a need to improve the ability of subunit vaccines to induce CD8(+) CTL responses in humans, especially for vaccines used to prevent illness by organisms that undergo antigenic variation at their major neutralizing antibody sites, e.g., influenza A viruses and human immunodeficiency virus. Murine models have demonstrated the protective role of cross-reactive CTL against influenza A virus antigenic drift. We tested the ability of an adjuvanted carrier (Iscomatrix) to help human antigen-presenting cells present formalin-killed influenza vaccine to human CD8(+) CTL clones in vitro and in vaccinated humans. The results of a randomized, double-blind, controlled clinical study demonstrate that a single dose of a vaccine formulated into Iscom particles increased influenza A virus-specific CTL memory in 50-60% of recipients, compared to 5% of the recipients of the standard influenza vaccine.Source
Virology. 1999 Jul 5;259(2):256-61. Link to article on publisher's siteDOI
10.1006/viro.1999.9765Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33677PubMed ID
10388649Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1006/viro.1999.9765