Title

Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS)

Student Author(s)

Julie Marie Jameson

GSBS Program

Immunology & Virology Program

UMMS Affiliation

Center for Infectious Disease and Vaccine Research

Date

7-5-1999

Document Type

Article

Medical Subject Headings

Adolescent; Adult; Double-Blind Method; Humans; ISCOMs; *Immunologic Memory; Influenza A virus; Influenza Vaccines; Middle Aged; T-Lymphocytes, Cytotoxic; Vaccination

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

There is a need to improve the ability of subunit vaccines to induce CD8(+) CTL responses in humans, especially for vaccines used to prevent illness by organisms that undergo antigenic variation at their major neutralizing antibody sites, e.g., influenza A viruses and human immunodeficiency virus. Murine models have demonstrated the protective role of cross-reactive CTL against influenza A virus antigenic drift. We tested the ability of an adjuvanted carrier (Iscomatrix) to help human antigen-presenting cells present formalin-killed influenza vaccine to human CD8(+) CTL clones in vitro and in vaccinated humans. The results of a randomized, double-blind, controlled clinical study demonstrate that a single dose of a vaccine formulated into Iscom particles increased influenza A virus-specific CTL memory in 50-60% of recipients, compared to 5% of the recipients of the standard influenza vaccine.

Rights and Permissions

Citation: Virology. 1999 Jul 5;259(2):256-61. Link to article on publisher's site

Related Resources

Link to article in PubMed

PubMed ID

10388649