GSBS Student Publications

Title

microPrimer: the biogenesis and function of microRNA

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Pharmacology

Date

10-15-2005

Document Type

Article

Medical Subject Headings

Animals; Gene Expression Regulation, Developmental; Humans; MicroRNAs; Plants; RNA, Messenger

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes. miRNAs are found only in plants and animals, and in the viruses that infect them. miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression.

Rights and Permissions

Citation: Development. 2005 Nov;132(21):4645-52. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Development (Cambridge, England)

PubMed ID

16224044