Centrosome control of the cell cycle
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Medical Subject Headings
Aneuploidy; Animals; *Cell Cycle; Centrosome; Humans; Signal Transduction; Tubulin
Life Sciences | Medicine and Health Sciences
Early observations of centrosomes, made a century ago, revealed a tiny dark structure surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are microtubules and that the dark organelles are centrosomes that mediate functions far beyond the more conventional role of microtubule organization. More recent evidence demonstrates that the centrosome serves as a scaffold for anchoring an extensive number of regulatory proteins. Among these are cell-cycle regulators whose association with the centrosome is an essential step in cell-cycle control. Such studies show that the centrosome is required for several cell-cycle transitions, including G(1) to S-phase, G(2) to mitosis and metaphase to anaphase. In this review (which is part of the Chromosome Segregation and Aneuploidy series), we discuss recent data that provide the most direct links between centrosomes and cell-cycle progression.
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Citation: Trends Cell Biol. 2005 Jun;15(6):303-11. Link to article on publisher's site
Trends in cell biology
Doxsey, Stephen J.; Zimmerman, Wendy Cherie; and Mikule, Keith, "Centrosome control of the cell cycle" (2005). GSBS Student Publications. 324.