GSBS Student Publications

Title

Centrosome control of the cell cycle

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine

Date

6-15-2005

Document Type

Article

Medical Subject Headings

Aneuploidy; Animals; *Cell Cycle; Centrosome; Humans; Signal Transduction; Tubulin

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Early observations of centrosomes, made a century ago, revealed a tiny dark structure surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are microtubules and that the dark organelles are centrosomes that mediate functions far beyond the more conventional role of microtubule organization. More recent evidence demonstrates that the centrosome serves as a scaffold for anchoring an extensive number of regulatory proteins. Among these are cell-cycle regulators whose association with the centrosome is an essential step in cell-cycle control. Such studies show that the centrosome is required for several cell-cycle transitions, including G(1) to S-phase, G(2) to mitosis and metaphase to anaphase. In this review (which is part of the Chromosome Segregation and Aneuploidy series), we discuss recent data that provide the most direct links between centrosomes and cell-cycle progression.

Rights and Permissions

Citation: Trends Cell Biol. 2005 Jun;15(6):303-11. Link to article on publisher's site

DOI of Published Version

10.1016/j.tcb.2005.04.008

Related Resources

Link to article in PubMed

Journal Title

Trends in cell biology

PubMed ID

15953548