Title
Membrane recognition and targeting by lipid-binding domains
GSBS Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology
Date
12-18-2003
Document Type
Article
Medical Subject Headings
Animals; Humans; *Lipid Metabolism; Lipids; Membrane Microdomains; Protein Binding; Protein Structure, Tertiary
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.
Rights and Permissions
Citation: Sci STKE. 2003 Dec 16;2003(213):re16. Link to article on publisher's site