GSBS Student Publications


Membrane recognition and targeting by lipid-binding domains

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology



Document Type


Medical Subject Headings

Animals; Humans; *Lipid Metabolism; Lipids; Membrane Microdomains; Protein Binding; Protein Structure, Tertiary


Life Sciences | Medicine and Health Sciences


Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.

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Citation: Sci STKE. 2003 Dec 16;2003(213):re16. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to article in PubMed

Journal Title

Science's STKE : signal transduction knowledge environment

PubMed ID