GSBS Student Publications

Title

Membrane recognition and targeting by lipid-binding domains

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology

Date

12-18-2003

Document Type

Article

Medical Subject Headings

Animals; Humans; *Lipid Metabolism; Lipids; Membrane Microdomains; Protein Binding; Protein Structure, Tertiary

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.

Rights and Permissions

Citation: Sci STKE. 2003 Dec 16;2003(213):re16. Link to article on publisher's site

DOI of Published Version

10.1126/stke.2132003re16

Related Resources

Link to article in PubMed

Journal Title

Science's STKE : signal transduction knowledge environment

PubMed ID

14679290