Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Medicine, Division of Diabetes
Medical Subject Headings
Adult; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD40; Antigens, CD80; Antigens, CD86; B-Lymphocytes; CD40 Ligand; Cell Differentiation; Cell Transplantation; Graft Survival; Humans; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, SCID; T-Lymphocytes; Tetanus Toxoid; Transplantation, Heterologous
Life Sciences | Medicine and Health Sciences
Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells.
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Citation: Cell Transplant. 1998 Jan-Feb;7(1):25-35.
Foy, Teresa M.; McIlraith, Melissa; Masters, Sally R.; Dunn, Jonathan J.; Rossini, Aldo A.; Shultz, Leonard D.; Hesselton, RuthAnn M.; Wagar, Eric James; Lipsky, Peter E.; Noelle, Randolph J.; and Greiner, Dale L., "Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice" (1998). GSBS Student Publications. 306.