GSBS Student Publications

Title

Establishment of interference in osteoblasts by an osteopetrosis-inducing avian leukosis virus

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences

Date

11-15-1994

Document Type

Article

Medical Subject Headings

Animals; Avian leukosis virus; Cells, Cultured; Chick Embryo; Osteoblasts; Osteopetrosis; *Viral Interference

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Avian leukosis virus (ALV)-induced osteopetrosis is characterized by the presence of unintegrated viral DNA is diseased bone. To learn more about this phenomenon, ALVs with high (Br21) and low (RAV-1) osteopetrotic potential have been compared for the ability to establish superinfection resistance in cultures of calvarial-derived osteoblasts. Both viruses could establish interference in osteoblast cultures that were maintained as growing cells. This interference was maintained when cultures were induced to differentiate. These results suggest that the unintegrated viral DNA in osteopetrotic bone is not due to the inability of osteopetrosis-inducing viruses to establish superinfection resistance in osteoblasts.

Rights and Permissions

Citation: Virology. 1994 Nov 15;205(1):376-8. Link to article on publisher's site

DOI of Published Version

10.1006/viro.1994.1656

Related Resources

Link to article in PubMed

Journal Title

Virology

PubMed ID

7975235