GSBS Student Publications

Title

Effects of calcium, ATP, and lipids on human erythrocyte sugar transport

Student Author(s)

Daniel N. Hebert

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

12-1-1989

Document Type

Article

Medical Subject Headings

Adenosine Triphosphate; Biological Transport; Calcium; *Carbohydrate Metabolism; Erythrocytes; Humans; Lipid Bilayers

Disciplines

Biochemistry, Biophysics, and Structural Biology | Life Sciences | Medicine and Health Sciences

Abstract

Human red cell sugar transport shows profound changes upon cellular aging.' As the human erythrocyte glucose transport protein shares more than 98% primary, structural homology with the rat and rabbit brain glucose transport can be isolated from human red cells in large (mg) quantities and, owing to the relative ease of manipulation of red cell contents by forming resealed ghosts, erythrocyte sugar transport may provide a useful experimental model for the study of the effects of the aging process on a protein-mediated membrane process. In this short paper we examine how the catalytic activity of the human erythrocyte glucose transport protein is modified by intracellular ATP and calcium, by extracellular calcium, and by the physical and compositional properties of its resident membrane bilayer.

Rights and Permissions

Citation: Ann N Y Acad Sci. 1989;568:52-67. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Annals of the New York Academy of Sciences

PubMed ID

2698078