Title
Endotoxin recognition and signal transduction by the TLR4/MD2-complex
GSBS Program
Immunology & Virology Program
UMMS Affiliation
Department of Medicine, Division of Infectious Diseases and Immunology
Date
12-15-2004
Document Type
Article
Medical Subject Headings
Animals; Antigens, Surface; Carrier Proteins; Endotoxins; Lipopolysaccharides; Lymphocyte Antigen 96; Membrane Glycoproteins; Receptors, Cell Surface; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors
Disciplines
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences
Abstract
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.
Rights and Permissions
Citation: Microbes Infect. 2004 Dec;6(15):1361-7. Link to article on publisher's site