Endotoxin recognition and signal transduction by the TLR4/MD2-complex
Immunology & Virology Program
Department of Medicine, Division of Infectious Diseases and Immunology
Medical Subject Headings
Animals; Antigens, Surface; Carrier Proteins; Endotoxins; Lipopolysaccharides; Lymphocyte Antigen 96; Membrane Glycoproteins; Receptors, Cell Surface; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.
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Citation: Microbes Infect. 2004 Dec;6(15):1361-7. Link to article on publisher's site
Microbes and infection / Institut Pasteur
Fitzgerald, Katherine A.; Rowe, Daniel C.; and Golenbock, Douglas T., "Endotoxin recognition and signal transduction by the TLR4/MD2-complex" (2004). GSBS Student Publications. 293.