GSBS Student Publications

Title

Endotoxin recognition and signal transduction by the TLR4/MD2-complex

Student Author(s)

Daniel C. Rowe

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

12-15-2004

Document Type

Article

Medical Subject Headings

Animals; Antigens, Surface; Carrier Proteins; Endotoxins; Lipopolysaccharides; Lymphocyte Antigen 96; Membrane Glycoproteins; Receptors, Cell Surface; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.

Rights and Permissions

Citation: Microbes Infect. 2004 Dec;6(15):1361-7. Link to article on publisher's site

DOI of Published Version

10.1016/j.micinf.2004.08.015

Related Resources

Link to article in PubMed

Journal Title

Microbes and infection / Institut Pasteur

PubMed ID

15596121