GSBS Student Publications

Title

Tec kinases in T cell and mast cell signaling

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Date

3-27-2007

Document Type

Article

Medical Subject Headings

Animals; Enzyme Activation; Humans; Mast Cells; Protein-Tyrosine Kinases; Signal Transduction; T-Lymphocytes

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The Tec family of tyrosine kinases consists of five members (Itk, Rlk, Tec, Btk, and Bmx) that are expressed predominantly in hematopoietic cells. The exceptions, Tec and Bmx, are also found in endothelial cells. Tec kinases constitute the second largest family of cytoplasmic protein tyrosine kinases. While B cells express Btk and Tec, and T cells express Itk, Rlk, and Tec, all four of these kinases (Btk, Itk, Rlk, and Tec) can be detected in mast cells. This chapter will focus on the biochemical and cell biological data that have been accumulated regarding Itk, Rlk, Btk, and Tec. In particular, distinctions between the different Tec kinase family members will be highlighted, with a goal of providing insight into the unique functions of each kinase. The known functions of Tec kinases in T cell and mast cell signaling will then be described, with a particular focus on T cell receptor and mast cell Fc epsilon RI signaling pathways.

Rights and Permissions

Citation: Adv Immunol. 2007;93:145-84. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Advances in immunology

PubMed ID

17383541