Eater: a big bite into phagocytosis
Graduate School of Biomedical Sciences; Department of Medicine, Division of Infectious Disease and Immunology
Medical Subject Headings
Amino Acid Motifs; Amino Acid Sequence; Animals; Bacterial Infections; Conserved Sequence; Drosophila; Embryo, Nonmammalian; Escherichia coli; Frameshift Mutation; Genes, Insect; Insect Proteins; Macrophages; Membrane Proteins; Microarray Analysis; Molecular Sequence Data; Mutagenesis; *Phagocytosis; Protein Structure, Tertiary; RNA Interference; Receptors, Scavenger; Sequence Homology, Amino Acid; Serratia marcescens
Life Sciences | Medicine and Health Sciences
The phagocytosis of invading microorganisms by specialized blood cells is a crucial element of innate immunity in both mammals and insects. In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila.
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Citation: Cell. 2005 Oct 21;123(2):190-2. Link to article on publisher's site