Title
A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
GSBS Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Date
2-26-2004
Document Type
Article
Medical Subject Headings
*Combinatorial Chemistry Techniques; Dipeptides; Mass Spectrometry; Peptide Library; Peptidyl Transferases; RNA, Catalytic
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.
Rights and Permissions
Citation: Bioorg Med Chem. 2004 Mar 1;12(5):927-33. Link to article on publisher's site