GSBS Student Publications


A peptidyl transferase ribozyme capable of combinatorial peptide synthesis

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine



Document Type


Medical Subject Headings

*Combinatorial Chemistry Techniques; Dipeptides; Mass Spectrometry; Peptide Library; Peptidyl Transferases; RNA, Catalytic


Life Sciences | Medicine and Health Sciences


The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.

Rights and Permissions

Citation: Bioorg Med Chem. 2004 Mar 1;12(5):927-33. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Bioorganic and medicinal chemistry

PubMed ID