A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Medical Subject Headings
*Combinatorial Chemistry Techniques; Dipeptides; Mass Spectrometry; Peptide Library; Peptidyl Transferases; RNA, Catalytic
Life Sciences | Medicine and Health Sciences
The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.
Rights and Permissions
Citation: Bioorg Med Chem. 2004 Mar 1;12(5):927-33. Link to article on publisher's site
Bioorganic and medicinal chemistry
Cui, Zhiyong; Sun, Lele; and Zhang, Biliang, "A peptidyl transferase ribozyme capable of combinatorial peptide synthesis" (2004). GSBS Student Publications. 257.