The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Cell Biology; Department of Anatomy
Medical Subject Headings
Alveolar Process; Animals; Animals, Newborn; Bone Resorption; Cell Count; Dental Sac; Drug Combinations; Epidermal Growth Factor; Incisor; Leukocyte Count; Leukocytes, Mononuclear; Macrophage Colony-Stimulating Factor; Microscopy, Electron, Scanning; Molar; Osteoclasts; Rats; Tooth Eruption
Life Sciences | Medicine and Health Sciences
Both epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1 micrograms/g body weight) and CSF-1 (10(6) units) alone or together on the eruption of incisors and first molars. EGF accelerated the eruption of incisors with no significant effect on first molars. CSF-1, in contrast, accelerated molar eruption more than incisor eruption. CSF-1, but not EGF, increased the numbers of mononuclear cells in the dental follicle and osteoclasts on adjacent alveolar bone surfaces around the first molar and produced enhanced resorption of crypt surfaces as revealed by scanning electron microscopy. These data suggest that during eruption rodent incisors and molars may preferentially respond to different molecular regulators.
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Citation: Connect Tissue Res. 1995;32(1-4):165-9.
Connective tissue research
Cielinski, Matthew J.; Jolie, M.; Wise, Gary E.; and Marks, Sandy C., "The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat" (1995). GSBS Student Publications. 227.