Title

Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology

Date

10-23-2001

Document Type

Article

Medical Subject Headings

Administration, Intranasal; Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Humans; Immunization; *Immunologic Memory; Interferon Type II; Lung; Lymphocyte Activation; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred C57BL; Nasal Mucosa; Organ Specificity; Respiratory Tract Infections; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Vaccinia; Vaccinia virus

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.

Rights and Permissions

Citation: Nat Immunol. 2001 Nov;2(11):1067-76. Link to article on publisher's site

Related Resources

Link to article in PubMed