Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung
Authors
Chen, Hong D.Fraire, Armando E.
Joris, Isabelle
Brehm, Michael A.
Welsh, Raymond M.
Selin, Liisa K.
UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyDepartment of Pathology
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2001-10-23Keywords
Administration, Intranasal; Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Humans; Immunization; *Immunologic Memory; Interferon Type II; Lung; Lymphocyte Activation; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred C57BL; Nasal Mucosa; Organ Specificity; Respiratory Tract Infections; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Vaccinia; Vaccinia virusLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.Source
Nat Immunol. 2001 Nov;2(11):1067-76. Link to article on publisher's siteDOI
10.1038/ni727Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33484PubMed ID
11668342Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/ni727
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