GSBS Student Publications

Student Author(s)

Rhonda L. McFleder

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Program in Molecular Medicine

Date

7-18-2017

Document Type

Article

Disciplines

Biochemistry | Molecular and Cellular Neuroscience

Abstract

Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper control of this local translation. Here, we find that the deadenylase CNOT7 dynamically regulates dendritic mRNA translation and transport, as well as synaptic plasticity and higher cognitive function. In cultured hippocampal neurons, synaptic stimulation induces a rapid decrease in CNOT7, which, in the short-term, results in poly(A) tail lengthening of target mRNAs. However, at later times following stimulation, decreased poly(A) and dendritic localization of mRNA take place, similar to what is observed when CNOT7 is depleted over several days. In mice, CNOT7 is essential for hippocampal-dependent learning and memory. This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function.

Rights and Permissions

Copyright 2017 The Author(s)

DOI of Published Version

10.1016/j.celrep.2017.06.078

Source

Cell Rep. 2017 Jul 18;20(3):683-696. doi: 10.1016/j.celrep.2017.06.078. Link to article on publisher's website

Related Resources

Link to article in PubMed

Keywords

CNOT7, polyadenylation, deadenylation, translation, RNA transport

Journal Title

Cell Reports

PubMed ID

28723570

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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