S. pombe FEAR protein orthologs are not required for release of Clp1/Flp1 phosphatase from the nucleolus during mitosis
UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2006-10-13Keywords
Active Transport, Cell Nucleus; Cell Cycle Proteins; Cell Nucleolus; Cell Nucleus; Chromosome Segregation; Fluorescence; Gene Expression Regulation, Fungal; Mitosis; Mitotic Spindle Apparatus; Phosphoprotein Phosphatases; Protein Tyrosine Phosphatases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; TelomereLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Cdc14 family phosphatases are highly conserved regulators of cell-cycle progression. Two of the best studied members of this family are budding yeast Cdc14p and its fission yeast homolog Clp1p/Flp1p. The function of both Saccharomyces cerevisiae Cdc14p and Schizosaccharomyces pombe Clp1p/Flp1p are controlled in part by their regulated sequestration and release from the nucleolus. In the budding yeast S. cerevisiae a set of proteins collectively termed the FEAR network promote nucleolar and telomeric DNA segregation by triggering the release of the conserved Cdc14 phosphatase from the nucleolus. Here we show that FEAR homologs in S. pombe do not promote release of the Cdc14 homolog Clp1p/Flp1p from the nucleolus, and that Clp1p/Flp1p is not required for nucleolar and telomeric DNA segregation suggesting that this aspect of Cdc14 regulation and function may not be universally conserved.Source
J Cell Sci. 2006 Nov 1;119(Pt 21):4462-6. Epub 2006 Oct 10. Link to article on publisher's siteDOI
10.1242/jcs.03220Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33460PubMed ID
17032733Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1242/jcs.03220