GSBS Student Publications

Student Author(s)

Christopher J. Burke

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

3-16-2015

Document Type

Article

Disciplines

Behavioral Neurobiology

Abstract

Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the beta'2 and gamma4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the gamma5b regions, and it can be artificially reinforced by those projecting to the beta lobe and adjacent alpha1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.

Rights and Permissions

Citation: Curr Biol. 2015 Mar 16;25(6):751-8. doi: 10.1016/j.cub.2015.01.036. Epub 2015 Feb 26. Link to article on publisher's site

Comments

Co-author Christopher J. Burke is a doctoral student in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources

Link to Article in PubMed

Journal Title

Current biology : CB

PubMed ID

25728694

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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