GSBS Student Publications

Title

Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization

Student Author(s)

Shun-Jen Yang

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Tzumin Lee Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

5-3-2007

Document Type

Article

Medical Subject Headings

Animals; Animals, Genetically Modified; Cell Adhesion Molecules; Cell Shape; Dendrites; Drosophila; Drosophila Proteins; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Mutation; Neurons, Afferent; Sense Organs; Staining and Labeling

Disciplines

Developmental Neuroscience

Abstract

A neuron's dendrites typically do not cross one another. This intrinsic self-avoidance mechanism ensures unambiguous processing of sensory or synaptic inputs. Moreover, some neurons respect the territory of others of the same type, a phenomenon known as tiling. Different types of neurons, however, often have overlapping dendritic fields. We found that Down's syndrome Cell Adhesion Molecule (Dscam) is required for dendritic self-avoidance of all four classes of Drosophila dendritic arborization (da) neurons. However, neighboring mutant class IV da neurons still exhibited tiling, suggesting that self-avoidance and tiling differ in their recognition and repulsion mechanisms. Introducing 1 of the 38,016 Dscam isoforms to da neurons in Dscam mutants was sufficient to significantly restore self-avoidance. Remarkably, expression of a common Dscam isoform in da neurons of different classes prevented their dendrites from sharing the same territory, suggesting that coexistence of dendritic fields of different neuronal classes requires divergent expression of Dscam isoforms.

Rights and Permissions

Citation: Neuron. 2007 May 3;54(3):403-16. Link to article on publisher's site

DOI of Published Version

10.1016/j.neuron.2007.03.029

Related Resources

Link to Article in PubMed

Journal Title

Neuron

PubMed ID

17481394