GSBS Student Publications

Student Author(s)

Pallavi Lamba

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

5-8-2014

Document Type

Article

Medical Subject Headings

Amino Acid Sequence; Animals; Circadian Rhythm; Cryptochromes; Drosophila; Drosophila Proteins; F-Box Proteins; *Light; Molecular Sequence Data; Mutagenesis; Neurons; RNA Interference; Sequence Alignment

Disciplines

Behavioral Neurobiology | Cell Biology | Cellular and Molecular Physiology

Abstract

Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM), and promotes its degradation, which is mediated by JETLAG (JET). However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M) and the evening (E) oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.

Rights and Permissions

Citation: Cell Rep. 2014 May 8;7(3):601-8. doi: 10.1016/j.celrep.2014.03.044. Epub 2014 Apr 17. Link to article on publisher's site

DOI of Published Version

10.1016/j.celrep.2014.03.044

Comments

Copyright © 2014 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Related Resources

Link to Article in PubMed

Journal Title

Cell reports

PubMed ID

24746814

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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