Mechanisms underlying nucleosome positioning in vivo
Biochemistry & Molecular Pharmacology
Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Animals; Chromatin Assembly and Disassembly; DNA; Eukaryota; Humans; Nucleosomes
Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biophysics
It has been some 40 years since repeating subunits in eukaryotic chromatin, initially termed "nu bodies," were described. Four decades of study have characterized the structural organization of the nucleosome, from multiple crystal structures of individual nucleosomes to genome-wide maps of nucleosome positions in scores of organisms. Nucleosome positioning can impact essentially all DNA-templated processes, making an appreciation of the forces shaping the nucleosomal landscape in eukaryotes key to fully understanding genomic regulation. Here, we review the factors impacting nucleosome positioning and the ways that nucleosomes can control the output of the genome.
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Citation: Annu Rev Biophys. 2014;43:41-63. doi: 10.1146/annurev-biophys-051013-023114. Link to article on publisher's site
Annual review of biophysics
Hughes, Amanda and Rando, Oliver J., "Mechanisms underlying nucleosome positioning in vivo" (2014). GSBS Student Publications. 1931.