GSBS Student Publications


Mechanisms underlying nucleosome positioning in vivo

Student Author(s)

Amanda L. Hughes

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology



Document Type


Medical Subject Headings

Animals; Chromatin Assembly and Disassembly; DNA; Eukaryota; Humans; Nucleosomes


Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biophysics


It has been some 40 years since repeating subunits in eukaryotic chromatin, initially termed "nu bodies," were described. Four decades of study have characterized the structural organization of the nucleosome, from multiple crystal structures of individual nucleosomes to genome-wide maps of nucleosome positions in scores of organisms. Nucleosome positioning can impact essentially all DNA-templated processes, making an appreciation of the forces shaping the nucleosomal landscape in eukaryotes key to fully understanding genomic regulation. Here, we review the factors impacting nucleosome positioning and the ways that nucleosomes can control the output of the genome.

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Citation: Annu Rev Biophys. 2014;43:41-63. doi: 10.1146/annurev-biophys-051013-023114. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal Title

Annual review of biophysics

PubMed ID