RNA Therapeutics Institute
Molecular and Cellular Neuroscience | Nervous System Diseases | Neurology | Neuroscience and Neurobiology
BACKGROUND: Neuromyelitis optica (NMO) is a devastating inflammatory disorder of the optic nerves and spinal cord characterized by frequently recurring exacerbations of humoral inflammation. NMO is associated with the highly specific NMO-IgG biomarker, an antibody that binds the aquaporin-4 water channel. Aquaporin-4 is present on glial endfeet in the central nervous system (CNS). In humans, the NMO-IgG portends more frequent exacerbations and a worse long-term clinical outcome.
METHODS: We tested the longer-term outcome of mice with EAE injected with NMO-IgG and followed them for 60 days. Clinical exams and pathology of the spinal cord and optic nerves were compared to mice that received control human IgG.
RESULTS: Passively transferred human NMO-IgG leads to more severe neurology disability over two months after onset of disease. Clinical worsening is associated with an increased concentration of large demyelinating lesions primarily to subpial AQP4-rich regions of the spinal cord.
CONCLUSIONS: NMO-IgG is pathogenic in the context of EAE in mice.
Neuromyelitis optica, Aquaporin-4, NMO-IgG, Astrocytes, Experimental autoimmune encephalomyelitis
Saini, Harleen; Rifkin, Robert; Gorelik, Michael; Huang, Hwa; Ferguson, Zachary; Jones, Melina V.; and Levy, Michael, "Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis" (2013). GSBS Student Publications. 1833.