GSBS Student Publications

Title

Structure and function of nematode RNA-binding proteins

Student Author(s)

LiangMeng Wee

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

6-1-2010

Document Type

Article

Medical Subject Headings

Animals; Crystallography, X-Ray; Embryonic Development; Germ Cells; Humans; Nematoda; RNA-Binding Proteins; Substrate Specificity

Disciplines

Structural Biology

Abstract

RNA-binding proteins are critical effectors of gene expression. They guide mRNA localization, translation, and stability, and potentially play a role in regulating mRNA synthesis. The structural basis for RNA recognition by RNA-binding proteins is the key to understand how they target specific transcripts for regulation. Compared to other metazoans, nematode genomes contain a significant expansion in several RNA-binding protein families, including Pumilio-FBF (PUF), TTP-like zinc finger (TZF), and Argonaute-like (AGO) proteins. Genetic data suggest that individual members of each family have distinct functions, presumably due to sequence variations that alter RNA-binding specificity or protein interaction partners. In this review, we highlight example structures and identify the variable regions that likely contribute to functional divergence in nematodes.

Rights and Permissions

Citation: Curr Opin Struct Biol. 2010 Jun;20(3):305-12. doi: 10.1016/j.sbi.2010.03.010. Link to article on publisher's website

Related Resources

Link to article in PubMed

Journal Title

Current opinion in structural biology

PubMed ID

20418095