Structure and function of nematode RNA-binding proteins
Interdisciplinary Graduate Program
Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Animals; Crystallography, X-Ray; Embryonic Development; Germ Cells; Humans; Nematoda; RNA-Binding Proteins; Substrate Specificity
RNA-binding proteins are critical effectors of gene expression. They guide mRNA localization, translation, and stability, and potentially play a role in regulating mRNA synthesis. The structural basis for RNA recognition by RNA-binding proteins is the key to understand how they target specific transcripts for regulation. Compared to other metazoans, nematode genomes contain a significant expansion in several RNA-binding protein families, including Pumilio-FBF (PUF), TTP-like zinc finger (TZF), and Argonaute-like (AGO) proteins. Genetic data suggest that individual members of each family have distinct functions, presumably due to sequence variations that alter RNA-binding specificity or protein interaction partners. In this review, we highlight example structures and identify the variable regions that likely contribute to functional divergence in nematodes.
Rights and Permissions
Citation: Curr Opin Struct Biol. 2010 Jun;20(3):305-12. doi: 10.1016/j.sbi.2010.03.010. Link to article on publisher's website
Current opinion in structural biology
Kaymak, Ebru; Wee, LiangMeng; and Ryder, Sean P., "Structure and function of nematode RNA-binding proteins" (2010). GSBS Student Publications. 1831.