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Student Authors
LiangMeng WeeUMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyDocument Type
Journal ArticlePublication Date
2010-06-01Keywords
Animals; Crystallography, X-Ray; Embryonic Development; Germ Cells; Humans; Nematoda; RNA-Binding Proteins; Substrate SpecificityStructural Biology
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Show full item recordAbstract
RNA-binding proteins are critical effectors of gene expression. They guide mRNA localization, translation, and stability, and potentially play a role in regulating mRNA synthesis. The structural basis for RNA recognition by RNA-binding proteins is the key to understand how they target specific transcripts for regulation. Compared to other metazoans, nematode genomes contain a significant expansion in several RNA-binding protein families, including Pumilio-FBF (PUF), TTP-like zinc finger (TZF), and Argonaute-like (AGO) proteins. Genetic data suggest that individual members of each family have distinct functions, presumably due to sequence variations that alter RNA-binding specificity or protein interaction partners. In this review, we highlight example structures and identify the variable regions that likely contribute to functional divergence in nematodes.Source
Curr Opin Struct Biol. 2010 Jun;20(3):305-12. doi: 10.1016/j.sbi.2010.03.010. Link to article on publisher's websiteDOI
10.1016/j.sbi.2010.03.010Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33302PubMed ID
20418095Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.sbi.2010.03.010