The role of MyD88 signaling in heterosubtypic influenza A virus infections
Immunology & Virology Program
Department of Medicine, Division of Infectious Diseases and Immunology
Medical Subject Headings
Myeloid Differentiation Factor 88; Toll-Like Receptor 7; Influenza A virus
Immunology and Infectious Disease | Virology | Virus Diseases
A mouse model of heterosubtypic influenza A virus infections was used to determine the role of MyD88 signaling in CD4+ T-cell, CD8+ T-cell, and IgG immune responses. We found that MyD88 signaling played an important role in anti-influenza A virus heterosubtypic lung and spleen CD4+ T-cell, and spleen CD8+ T-cell, immune responses. MyD88 dependent signaling was important for T-helper 1 cytokine production in anti-influenza A virus lung and spleen heterosubtypic CD4+ T-cells, but not for their frequencies. Toll-like receptor 7 dependent signaling played a partial role in anti-influenza A virus lung heterosubtypic CD4+ T-helper 1 responses and anti-influenza A virus heterosubtypic IgG2c antibody levels. Our results have important implications for the generation of effective universal influenza vaccines.
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Citation: Virus Res. 2013 Jan;171(1):216-21. doi: 10.1016/j.virusres.2012.12.004. Link to article on publisher's website
Madera, Rachel F. and Libraty, Daniel H., "The role of MyD88 signaling in heterosubtypic influenza A virus infections" (2013). GSBS Student Publications. 1824.